This article addresses three questions concerning the legal regulation of the use of race as a category in biomedical research: how does the law currently encourage the use of race in biomedical research?; how might the existing legal framework constrain its use?; and what should be the law's approach to race-based biomedical research? It proposes a social justice approach that aims to promote racial equality by discouraging the use of “race” as a biological category while encouraging its use as a (...) socio-political category to understand and investigate ways to eliminate disparities in health status, access to health care, and medical treatment. (shrink)

Public discourse on race-specific medicine typically erects a wall between the scientific use of race as a biological category and the ideological battle over race as a social identity. Scientists often address the potential for these therapeutics to reinforce a damaging understanding of “race” with precautions for using them rather than questioning their very development. For example, Esteban Gonzalez Burchard, an associate professor of medicine and biopharmaceutical sciences at the University of California, San Francisco, states, “We do see racial differences (...) between populations and shouldn’t just close our eyes. Unfortunately, race is a politically charged topic, and there will be evildoers. But the fear should not outweigh the benefit of looking.” Although it is recognized that ideology influences thesocialmeaning of race, it is usually assumed that there is a separate, prior scientific understanding of race that is not contaminated by politics. (shrink)

Public discourse on race-specific medicine typically erects a wall between the scientific use of race as a biological category and the ideological battle over race as a social identity. Scientists often address the potential for these therapeutics to reinforce a damaging understanding of “race” with precautions for using them rather than questioning their very development. For example, Esteban Gonzalez Burchard, an associate professor of medicine and biopharmaceutical sciences at the University of California, San Francisco, states, “We do see racial differences (...) between populations and shouldn’t just close our eyes. Unfortunately, race is a politically charged topic, and there will be evildoers. But the fear should not outweigh the benefit of looking.” Although it is recognized that ideology influences thesocialmeaning of race, it is usually assumed that there is a separate, prior scientific understanding of race that is not contaminated by politics. (shrink)

The scientific validity of racial categories has been the subject of debate among population geneticists, evolutionary biologists, and physical anthropologists for several decades. After World War II, the rejection of eugenics, which had supported sterilization laws and other destructive programs in the United States, generated a compelling critique of the biological basis of race. The classification of human beings into distinct biological “races” is a relatively recent invention propped up by deeply flawed evidence and historically providing the foundation of racist (...) ideology and inequities of power. Social scientists’ conclusion that race is socially constructed was confirmed by genomic studies of human variation, including the Human Genome Project, showing high levels of genetic similarity within the human species. Some scholars came to believe that the science of human genetic diversity would replace race as the preeminent means of grouping people for scientific purposes. (shrink)

Withholding or withdrawing life-saving ventilators can become necessary when resources are insufficient. In the USA, such rationing has unique social justice dimensions. Structural elements of dominant allocation frameworks simultaneously advantage white communities, and disadvantage Black communities—who already experience a disproportionate burden of COVID-19-related job losses, hospitalisations and mortality. Using the example of New Jersey’s Crisis Standard of Care policy, we describe how dominant rationing guidance compounds for many Black patients prior unfair structural disadvantage, chiefly due to the way creatinine and (...) life expectancy are typically considered.We outline six possible policy options towards a more just approach: improving diversity in decision processes, adjusting creatinine scores, replacing creatinine, dropping creatinine, finding alternative measures, adding equity weights and rejecting the dominant model altogether. We also contrast these options with making no changes, which is not a neutral default, but in separate need of justification, despite a prominent claim that it is simply based on ‘objective medical knowledge’. In the regrettable absence of fair federal guidance, hospital and state-level policymakers should reflect on which of these, or further options, seem feasible and justifiable.Irrespective of which approach is taken, all guidance should be supplemented with a monitoring and reporting requirement on possible disparate impacts. The hope that we will be able to continue to avoid rationing ventilators must not stand in the way of revising guidance in a way that better promotes health equity and racial justice, both to be prepared, and given the significant expressive value of ventilator guidance. (shrink)

We respond to recent comments on our proposal to improve justice in ventilator triage, in which we used as an example New Jersey’s publicly available and legally binding Directive Number 2020-03. We agree with Bernard Lo and Doug White that equity implications of triage frameworks should be continually reassessed, which is why we offered six concrete options for improvement, and called for monitoring the consequences of adopted triage models. We disagree with their assessment that we mis-characterised their Model Guidance, as (...) included in the NJ Directive, in ways that undermine our conclusions. They suggest we erroneously described their model as a two-criterion allocation framework; that recognising other operant criterion reveals it ‘likely mitigate[s] rather than exacerbate[s] racial disparities during triage’, and allege that concerns about inequitable outcomes are ‘without evidence’. We highlight two major studies robustly demonstrating why concerns about disparate outcomes are justified. We also show that White and Lo seek to retrospectively—and counterfactually—correct the version of the Model Guideline included in the NJ Directive. However, as our facsimile reproductions show, neither the alleged four-criteria form, nor other key changes, such as dropping the Sequential Organ Failure Assessment score, are found in the Directive. These points matter because our conclusions hence stand, because the public version of the Model Guidance had not been updated to reduce the risk of inequitable outcomes until June 2021 and NJ’s Directive still does not reflect these revisions, and, hence, represents a less equitable version, as acknowledged by its authors. We comment on broader policy implications and call for ways of ensuring accurate, transparent and timely updates for users of high-stakes guidelines. (shrink)

Volume 39 of the Tanner Lectures on Human Values includes lectures initially scheduled during the academic year 2019-2020. Owing to the global coronavirus pandemic, some were delivered at a later date. The Tanner Lectures are published in an annual volume. In addition to permanent lectures at nine universities, the Tanner Lectures on Human Values funds special one-time lectures at selected higher educational institutions in the United States and around the world.

Cesario misrepresents or ignores data on real-world racist and sexist patterns and processes in an attempt to discredit the assumptions of implicit bias experimentation. His position stands in stark contradiction to substantive research across the social sciences recognizing the widespread, systematic, and structuring processes of racism and sexism. We argue for centering the relationship between structural racism and individual bias.

In lieu of an abstract, here is a brief excerpt of the content:What Hume Actually Said About Miracles Robert J. Fogelin Two things are commonly said about Hume's treatment ofmiracles in the first part of Section X of the Enquiry Concerning Human Understanding: I.Hume did not put forward an a priori argument intended to show that miracles are not possible. II.Hume did put forward an a priori argument intended to show that testimony, however strong, could never make it reasonable to (...) believe that a miracle had occurred. In a recent article in this journal, Dorothy Coleman calls this the "traditional interpretation," and, since this characterization strikes me as correct, I shall call it that too. Antony Flew stands virtually alone in challenging the traditional interpretation, arguing, in particular, that Hume did not even attempt to provide an a priori argument showing that testimony can never establish the existence of a miracle. On FIeW1S reading, Hume's argument was intended to do no more than place a "check" on arguments put forward to establish the existence of miracles on the basis oftestimony. Along with others, however, Flew accepts the first partofthe traditional interpretation, namely, that whatever Hume was up to, he was certainly not trying to produce a proof showing that miracles cannot exist. He endorses the first part of the traditional interpretation in these words: What [Hume] is trying to demonstrate a priori in Part I is: not that, as amatter offact, miracles do nothappen; but that, from the very nature of the concept — 'from the very nature of the fact' — there must be a conflict of evidence required to show that they do. In opposition to these united voices, I will argue that this consensus on the first part of the traditional interpretation is unfounded, for there are clear texts — at the very heart ofHume's discussion — that go dead against it. Volume XVI Number 1 81 ROBERT J. FOGELIN Two passages, which occur in the same paragraph, are particularly relevant to this discussion: Passage I. A miracle is a violation of the laws of nature; and as a firm and unalterable experience has established these laws, the proofagainst a miracle, from the very nature of the fact, is as entire as any argument from experience can possibly be imagined. (E 114, emphasis added) Passage II. There must...bea uniform experience against every miraculous event, otherwise the event would not merit that appellation. And as a uniform experience amounts to a proof, there is here a direct andfullproof, from the nature ofthe fact, against the existence ofany miracle; nor can such aproofbe destroyed, or the miracle rendered credible, but by an opposite proof, which is superior. (E 115, emphasis added in final clause) The clause nor such a proof be destroyed, or miracle rendered credible in Passage II is crucial for our purposes, for it simultaneously expresses two claims which, for clarity's sake, I will state separately. First, when Hume speaks??such a proof, he is referring to the direct and full proof, from the nature ofthe fact, against the existence ofany miracle mentioned in the first part of the same sentence. Thus, one thing that Hume is saying is this: Ci: Nor can such a proof(against the existence ofany miracle) be destroyed, but by an opposite proof which is superior. He is also making the following claim: C2: Nor can such a miracle be rendered credible, but by an opposite proof which is superior. Having sorted things out, it is now possible — using only direct quotations from the immediate text — to show that, contrary to the traditional interpretation, Hume does present an a priori argument against the existence ofmiracles. Argument One 1. there is here a direct and full proof, from the nature ofthe fact, against the existence ofany miracle; nor can such a proof be destroyed... but by an opposite proof, which is superior. (E 115, from Passage II) 82Hume Studies WHAT HUME ACTUALLY SAID ABOUT MIRACLES 2.the proofagainst a miracle, from the very nature ofthe fact, is as entire as any argument from experience can possibly be imagined. (E 114, emphasis added, from Passage I) Therefore: 3.there is... a direct andfullproof, from the nature ofthe fact, against the existence ofany miracle... (shrink)

At the occasion of the annual banquet of the Society for Social Studies of Science, the President commemorated Robert K. Merton, Dorothy Nelkin, and David Edge, who all died in 2003. The address highlights some of the contributions of these three scholars and past presidents to the development of the social studies of science, and to 4S.

This paper presents the leading idea of my doctoral dissertation and thus has been shaped by the reactions of all the members of my thesis committee: Charles Chastain, Walter Edelberg, W. Kent Wilson, Dorothy Grover, and Charles Marks. I am especially grateful for the help of Professors Chastain, Edelberg, and Wilson; each worked closely with me at one stage or another in the development of the ideas contained in the present work. Shorter versions of this paper were presented at (...) the 47th Annual Northwest Conference on Philosophy (1995), the 1996 Mid-South Philosophy Conference, the 1997 meeting of the Central Division of the American Philosophical Association, and at the University of Washington, Seattle; thanks to all audiences for their insightful comments and questions and also to my conference commentators, Eric Gampel, Jonathan Cohen, and Bruce Glymour, respectively, each of whom offered a thoughtful critique. Lastly, I extend my gratitude to anonymous referees, including two from Mind and Language, whose remarks led to significant improvements in the paper. Address for correspondence: 13416, 4th Ave. S., Seattle, WA 98168, USA E-mail: [email protected].. (shrink)

The article argues that Marx’s use of the concept of ideology in The German Ideology is incidental to a sustained critique of how those he described as the German ideologists think and reason about society and history and that this critique is not simply of an idealist theory that represents society and history as determined by consciousness but of methods of reasoning that treat concepts, even of those of political economy, as determinants. His view of how consciousness is determined historically (...) by our social being does not envisage some kind of mechanical transfer of class status to class consciousness. Rather, he works with an epistemology that takes the concepts foundational to political economy as expressions or reflections of the social relations of a mode of production. The difference between ideology and science is the difference between treating those concepts as the primitives of theory and treating them as sites for exploring the social relations that are expressed in them. Thus, the historical rather than further undermining claims to knowledge, provides both the conditions under which knowledge is possible and its limitations. (shrink)

Computer and video games have become nearly ubiquitous among individuals in industrialized nations, and they have received increasing attention from researchers across many areas of scientific study. However, relatively little attention has been given to Massively-Multiplayer Online Games . The unique social context of MMOGs raises ethical questions about how communication occurs and how conflict is managed in the game world. In order to explore these questions, we compare the social context in Blizzard’s World of Warcraft and Disney’s Toontown, focusing (...) on griefing opportunities in each game. We consider ethical questions from the perspectives of players, game companies, and policymakers. (shrink)

Pandemic plans are increasingly attending to groups experiencing health disparities and other social vulnerabilities. Although some pandemic guidance is silent on the issue, guidance that attends to socially vulnerable groups ranges widely, some procedural (often calling for public engagement), and some substantive. Public engagement objectives vary from merely educational to seeking reflective input into the ethical commitments that should guide pandemic planning and response. Some plans that concern rationing during a severe pandemic recommend ways to protect socially vulnerable groups without (...) prioritizing access to scarce resources based on social vulnerability per se. The Minnesota Pandemic Ethics Project (MPEP), a public engagement project on rationing scarce health resources during a severe influenza pandemic, agrees and recommends an integrated set of ways to attend to the needs of socially vulnerable people and avoid exacerbation of health disparities during a severe influenza pandemic. Among other things, MPEP recommends: 1. Engaging socially vulnerable populations to clarify unique needs and effective strategies; 2. Engaging socially vulnerable populations to elicit ethical values and perspectives on rationing; 3. Rejecting rationing based on race, socioeconomic class, citizenship, quality of life, length of life-extension and first-come, first-served; 4. Prioritizing those in the general population for access to resources based on combinations of risk (of death or severe complications from influenza, exposure to influenza, transmitting influenza to vulnerable groups) and the likelihood of responding well to the resource in question. 5. Protecting critical infrastructures on which vulnerable populations and the general public rely; 6. Identifying and removing access barriers during pandemic planning and response; and 7. Collecting and promptly analyzing data during the pandemic to identify groups at disproportionate risk of influenza-related mortality and serious morbidity and to optimize the distribution of resources. (shrink)

Telomeres are protective caps for chromosome ends that are essential for genome stability. Broken chromosomes missing a telomere will not be maintained unless the chromosome is ‘healed’ with the formation of a new telomere. Chromosome healing can be a programmed event following developmentally regulated chromosome fragmentation, or it may occur spontaneously when a chromosome is accidentally broken. In this article we discuss the consequences of telomere loss and the possible mechanisms that the enzyme telomerase employs to form telomeres de novo (...) on broken chromosome ends. (shrink)